‘GLP-1 Supreme’, ‘Support’ and GLP-1 drops: what’s in them and why they aren’t medicines

Products sold as ‘GLP-1 Supreme’, ‘GLP-1 Support’ or GLP-1 drops are marketed as food supplements, not medicines. They don’t reproduce the effect of semaglutide, and no health claim about GLP-1 or satiety is authorised in the European Union. They usually contain ingredients such as berberine, chromium, fibre or probiotics, which have small effects on weight. There is also no such thing as Wegovy drops or liquid Wegovy: in Spain, semaglutide is only sold as tablets or pens, on prescription and from a pharmacy.

What are ‘GLP-1 Supreme’, ‘Support’ supplements and GLP-1 drops?

They are products that borrow the name of the most searched-for medicine of the moment. A review for pharmacists, published in Pharmacy Times in May 2026, describes these over-the-counter ‘GLP-1 boosters’. They are promoted in pharmacies, online and on social media as natural alternatives, and their usual ingredients are berberine, chromium picolinate, resveratrol, fibre, green tea extract and probiotics. The same review concludes that they don’t reproduce the receptor activation or the clinical results of the medicines.

Each brand combines these ingredients in its own way, and we haven’t analysed the label of any specific product here, so what follows applies to the category as a whole. The underlying difference is one of scale. The GLP-1 your gut produces lasts 2 to 3 minutes in the bloodstream, while semaglutide lasts about a week. We explain how the real medicines work in what GLP-1 drugs are and how they work.

What does EU law say about these supplements?

A food supplement can only claim the effects listed in the EU register of authorised health claims, Regulation 432/2012. That list contains no claim about GLP-1, satiety or berberine. The closest are two statements. The glucomannan claim says that, ‘in the context of an energy-restricted diet, it contributes to weight loss’. It comes with a condition of 3 g a day in three 1 g doses taken with water before meals, plus a mandatory warning about the risk of choking. The chromium claim says it contributes to the maintenance of normal blood glucose levels, which is not the same as losing weight. Claims for meal replacements as part of an energy-restricted diet are also authorised.

In Spain, Royal Decree 1907/1996 also bans advertising for products with supposed health purposes that suggest specific slimming or anti-obesity properties, that use the word ‘natural’ as if it had therapeutic effects, that claim to replace medicines, or that suggest you can do without a doctor. An advert presenting drops as a natural GLP-1 that replaces the injection breaks several of those rules at once.

Do berberine, chromium or fibre work for weight loss?

Berberine

This is the most studied ingredient and the one most often sold as ‘natural Ozempic’. The most recent meta-analysis, covering 23 randomised trials, found an average reduction of 0.88 kg compared with control, 0.48 BMI points and 1.32 cm off the waist, and its authors call for better trials. Earlier meta-analyses ranged from no significant effect to around 2 kg. To put that figure in context: in the OASIS 4 trial, oral semaglutide achieved an average weight loss of 13.6% over 64 weeks, compared with 2.2% on placebo.

Safety is a bigger concern than effectiveness. The Spanish consumer organisation OCU advises against it. It describes diarrhoea, abdominal pain, nausea, hypotension, bradycardia and hypoglycaemia, interactions with up to 17 medicines, and points out that berberine crosses the placenta and passes into breast milk. On 22 April 2026, the European Food Safety Authority (EFSA) presented a draft opinion, still under consultation and not a final decision. It points to signs of genotoxicity in the laboratory that haven’t been confirmed in living organisms, the lack of a proper repeated-dose toxicity study, and digestive discomfort in trials using 400 to 1,500 mg a day. It also notes that berberine can inhibit CYP3A4, an enzyme that clears many drugs from the body. Based on these data, the draft concludes that a safe intake can’t be established.

Chromium, glucomannan and fibre

Chromium has an authorised claim about blood glucose, not about weight. Glucomannan is the only fibre with a weight-loss claim, and only as part of an energy-restricted diet. Without that diet, the claim can’t be used.

Probiotics and Akkermansia

The effect of a probiotic depends on the strain, and the EU list contains no claims about probiotics and weight. Pasteurised Akkermansia muciniphila is authorised in the EU as a novel food for use in supplements, up to 3.4 × 10^10 cells a day. It is still a food, though, and has no authorised claim about GLP-1 or weight.

Do Wegovy drops or liquid Wegovy exist?

No. CIMA, the register of the Spanish Agency of Medicines and Medical Devices (AEMPS), lists 38 semaglutide presentations, all from Novo Nordisk: 28 solutions for injection in pre-filled pens and 10 tablets. There are no drops, syrups or oral solutions, and no generics either. In Spain, Wegovy is available as 1.5, 4, 9 and 25 mg tablets and as pens, always on prescription and not funded by the Spanish National Health System. The generics already available in Canada and India are injectable pens.

Copies are circulating outside pharmacies. In September 2025 the AEMPS, together with the European Medicines Agency (EMA), warned of a sharp rise in illegal medicines sold as GLP-1 drugs through fraudulent websites and social media. These may not contain the stated active ingredient and may contain harmful substances. In 2023 the EMA found falsified Ozempic pens at European wholesalers, and in February 2026 Trinidad and Tobago issued a warning about falsified Wegovy tablets. Meanwhile, by 31 May 2026 the US Food and Drug Administration had received 990 adverse event reports involving compounded semaglutide, which it neither approves nor reviews, and it warns about products sold as ‘for research use only’.

The problem isn’t limited to GLP-1 products. On 2 September 2026 the AEMPS withdrew 22 slimming products that contained sibutramina, a drug banned in the EU because of its cardiovascular risks, and seven of them also contained phenolphthalein. According to the agency, they were presented as natural and hid their real composition.

How can you spot an illegal sale?

• It sells semaglutide, Wegovy-style pills or pens online or without a prescription: in Spain the law bans distance selling of prescription-only medicines (article 3.5 of Royal Legislative Decree 1/2015).
• The website isn’t a pharmacy, or doesn’t show the EU common logo: only authorised pharmacies that have registered the activity can sell online, they can only sell non-prescription medicines, and the logo links to the health authority so you can check (Royal Decree 870/2013).
• It advertises a prescription medicine to the public, on social media or by message: that kind of advertising is banned in Spain (article 80 of the same law).
• It promises weight loss, or presents itself as ‘natural’ or as a substitute for the medicine or for seeing a doctor: that is exactly the advertising Royal Decree 1907/1996 prohibits.
• It offers Wegovy or semaglutide drops, syrup or ‘liquid’, or something labelled ‘for research use only’: in Spain, none of these exist as an authorised medicine.

If you’ve already bought something like this, the sensible thing is not to take it and to talk to your doctor or pharmacist. We explain how the legal route works, with a prescription and a pharmacy, in our guide to buying Ozempic and Mounjaro in Spain legally and safely, and what to expect from an online medical service in our guide to choosing an online weight-loss clinic: what to compare and what to ask for.

What we know about the foods and habits that boost your own GLP-1 is covered in natural GLP-1, and the medicines backed by evidence in prescription weight-loss pills.

What are the alternatives if you really need to lose weight?

The key takeaway: a supplement with the medicine’s name on the label doesn’t contain it or mimic it. Anything sold as the medicine outside a pharmacy is illegal and may be fake.

If you need to lose weight with a doctor behind you, AiON offers medical weight-loss treatment with an initial assessment, a prescription from a registered doctor where appropriate, and ongoing follow-up. You can:

Check in a few minutes whether you’re eligible